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Product Name
Anti-IMP3 Rabbit antibody
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Description
IMP3 Rabbit monoclonal antibody
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Tested applications
WB, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human IMP3
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000
1:20
1:50
1:20
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Validations
Immunocytochemistry of IMP3(green) in Hela cells using IMP3 Rabbit mAb at dilution 1/200, and DAPI(blue)
Western blot detection of IMP3 in K562,Rat Brain,C6,3T3,Hela cell lysates using IMP3 Rabbit mAb(1:1000 diluted).Predicted band size:64kDa.Observed band size:64kDa.
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Background
Swiss-Prot Acc.O00425.RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"