NovoPro
Cart 2
  • Human FCGR2A/CD32/FCG2/FCGR2A1/IGFR2 (His tag) recombinant protein

Human FCGR2A/CD32/FCG2/FCGR2A1/IGFR2 (His tag) recombinant protein

Cat.#: 519570

Special Price 265.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human FCGR2A/CD32/FCG2/FCGR2A1/IGFR2 (His tag) recombinant protein
  • Documents
  • Description
    Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
  • Protein name
    Fc fragment of IgG receptor IIa(FCGR2A)
  • Protein short names
    CD32; FCG2; FCGR2A1; IGFR2
  • Uniprot ID
    P12318
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human FCGR2A/CD32/FCG2/FCGR2A1/IGFR2 Ala36-Ile218(His131Arg) is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human FCGR2A/CD32/FCG2/FCGR2A1/IGFR2 (His tag) recombinant protein

    Human FCGR2A/CD32/FCG2/FCGR2A1/IGFR2 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"