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Product Name
Human Ephrin-A3/EFNA3 recombinant protein
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Description
Ephrin-A3 also known as EPH-related receptor tyrosine kinase ligand 3 or EFNA3, is a member of the ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin-A3 and their Eph family of receptor tyrosine kinases are expressed by cells of the SVZ. Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: Ephrin-A3 ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A3 expressed on astrocytes activates EphA4 on the post-synaptic neuron and restricts the growth of dendritic spines through multiple pathways.
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Protein name
Ephrin-A3
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Protein short names
AW494418; LERK-3; LERK3; EPLG3; EHK1-L; EFL2; EPHRIN-A3; MGC129300; EPHRIN A3; EFL-2; EFNA3; EPL3; MGC129301
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Uniprot ID
P52797
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Gene Name
EFNA3; EFL2; EPLG3; LERK3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human EphrinA3 (NP_004943.1) (Met 1-Ser 213) with quinary-aa peptide (DDDDK) at the C-terminus was expressed and purified.
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Protein Species
Human
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Molecular weight
The recombinant human EphrinA3 consists of 197 amino acids and has a predicted molecular mass of 22 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhEphrinA3 is approximately 35-40 kDa due to glycosylation.
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Purity
> 70 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind biotinylated mouse EPHA6-Fc (Cat:501356) in a functional ELISA.
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Validations
Human Ephrin-A3 / EFNA3 Protein SDS-PAGE
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