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Product Name
Human Ephrin-A3/EFNA3 (His Tag) recombinant protein
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Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
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Protein name
Ephrin-A3
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Protein short names
EPL3; MGC129301; EFNA3; EFL-2; EPLG3; EHK1-L; EFL2; EPHRIN-A3; AW494418; LERK3; LERK-3; MGC129300; EPHRIN A3
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Uniprot ID
P52797
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Gene Name
EFNA3; EFL2; EPLG3; LERK3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human EphrinA3 (NP_004943.1) (Met 1-Ser 213) with the C-terminal propeptide removed was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human EphrinA3 consists of 202 amino acids after removal of the signal peptide and has a predicted molecular mass of 23 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhEphrinA3 is approximately 35-40 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to compete with human EphrinA3 / Fc for binding to immobilized mouse EphA6-his in a functional ELISA assay.
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Validations
Human Ephrin-A3 / EFNA3 Protein (His Tag) SDS-PAGE
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