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  • Human DLL4 recombinant protein (C-cleavage)
  • Human DLL4 recombinant protein (C-cleavage)

Human DLL4 recombinant protein (C-cleavage)

Cat.#: 514918

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Product Information

  • Product Name
    Human DLL4 recombinant protein (C-cleavage)
  • Documents
  • Description
    Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent studies yield substantial insights into the role of DLL4 in angiogenesis. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF. DLL4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of DLL4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. DLL4 is widely distributed in tissues other than vessels including many malignancies. Furthermore, the molecule is internalized on binding its receptor and often transported to the nucleus. In pathological conditions, such as cancer, DLL4 is up-regulated strongly in the tumour vasculature. Blockade of DLL4-mediated Notch signaling strikingly increases nonproductive angiogenesis, but significantly inhibits tumor growth in preclinical mouse models. In preclinical studies, blocking of DLL4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Thus, DLL4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy.
  • Protein name
    Delta-like protein 4
  • Protein short names
    Delta-like 4,hdelta2
  • Uniprot ID
    Q9NR61
  • Gene Name
    Delta-like protein 4; Drosophila Delta homolog 4; Delta4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human DLL4 (NP_061947.1) (Met1-Pro524) was expressed with five amino acids (DDDDK) at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human DLL4 consists of 504 amino acids and predicts a molecular mass of 55 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human DLL4/Delta-like 4 Protein 15517

    Human DLL4/Delta-like 4 Protein 15517

    Human DLL4 / Delta-like 4 Protein

    Human DLL4 / Delta-like 4 Protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"