• Human DLL4/Delta-like 4 (His Tag) recombinant protein

Human DLL4/Delta-like 4 (His Tag) recombinant protein

Cat.#: 500048

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Product Information

  • Product Name
    Human DLL4/Delta-like 4 (His Tag) recombinant protein
  • Documents
  • Description
    Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.
  • Protein name
    Delta-like protein 4
  • Protein short names
    DELTA 4; DLL4; DELTA4; HDELTA2; RP23-46P4.8; DELTA LIGAND 4; MGC126344
  • Uniprot ID
    Q9NR61
  • Gene Name
    DLL4; UNQ1895/PRO4341
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Pro 524) of human DLL4 (NP_061947.1) pro-protein was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human DLL4 consists of 509 amino acids and predicts a molecular mass of 55.7 kDa. As a result of glycosylation, the apparent molecular mass of rhDLL4 is approximately 55-70 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind human Notch1 in a functional ELISA.
    2. Measured by the ability of the immobilized protein to enhance BMP2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is typically 2-10 µg/mL in the presence of 500 ng/mL recombinant human BMP2.
  • Validations

    Human DLL4 / Delta4 Protein (His Tag) SDS-PAGE

    Human DLL4 / Delta4 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"