Human CD48/SLAMF2 (His Tag) recombinant protein
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.
Protein short names
BCM-1; BLAST; AW610730; AI449234; MEM-102; MCD48; CD48; SGP-60; BLAST-1; SLAMF2; BLAST1; HCD48; BCM1
CD48; BCM1; BLAST1
A DNA sequence encoding the human CD48 (NP_001769.2) (Met 1-Ser 220) with a C-terminal polyhistidine tag was expressed.
The secreted recombinant human CD48 comprises 205 amino acids with a predicted molecular mass of 23.8 kDa. As a result of glycosylation, rhCD48 migrates as an approximately 40 kDa band in SDS-PAGE under reducing conditions.
> 95 % as determined by SDS-PAGE
Measured by its binding ability in a functional ELISA. Immobilized human CD48 at 10 μg/ml (100 μl/well) can bind recombinant human 2B4 / CD244 with a linear range of 0.004-0.4 μg/ml.
Human CD48 / SLAMF2 / BCM1 Protein (His Tag) SDS-PAGE
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