Human ALK-4 / ACVR1B (His Tag) recombinant protein

Cat.#: 504100

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Product Information

  • Product Name
    Human ALK-4 / ACVR1B (His Tag) recombinant protein
  • Documents
  • Description
    ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
  • Protein name
    Activin receptor type-1B
  • Protein short names
    ALK-4; 6820432J04; ACVR1B; ACTR-IB; SKR2; ACVRLK4; ACTRIB; ALK4
  • Uniprot ID
    P36896
  • Gene Name
    ACVR1B; ACVRLK4; ALK4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human ACVR1B (NP_004293.1) extracellular domain (Met 1-Glu 126) was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human ACVR1B consists of 114 amino acids and has a predicted molecular mass of 13 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh ACVR1B is approximately 18-20 kDa due to glycosylation.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA. Immobilized human TDGF1 at 2 μg/ml (100 μl/well) can bind human ALK-4 with a linear range of 0.032-4 μg/ml.
  • Validations

    Human ALK4 / ACVR1B Protein (His Tag) SDS-PAGE

    Human ALK4 / ACVR1B Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"