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Product Name
Mouse ALK-4 / ACVR1B (Fc Tag) recombinant protein
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Description
ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
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Protein name
Receptor protein serine/threonine kinase
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Protein short names
ACVR1B; 6820432J04; ALK-4; ACTRIB; ACVRLK4; SKR2; ACTR-IB; ALK4
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Uniprot ID
Q61271
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Gene Name
Acvr1b
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Acvr1b (NP_031421.1) (Met1-Glu126) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Acvr1b consists 344 amino acids and predicts a molecular mass of 38.4 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Activity
Measured by its ability to bind with rat TDGF1-His (Cat:504857) in a functional ELISA.
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Validations
Mouse ALK-4 / ACVR1B Protein (Fc Tag) SDS-PAGE
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