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Product Name
Rhesus ALK-4 / ACVR1B (Fc Tag) recombinant protein
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Description
ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
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Protein name
Receptor protein serine/threonine kinase
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Protein short names
ALK4; ACVRLK4; ACTRIB; ACTR-IB; SKR2; ACVR1B; ALK-4; 6820432J04
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Uniprot ID
F7HNS7
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Gene Name
ACVR1B
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus ACVR1B (NP_001252559.1) (Met1-Glu126) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus ACVR1B comprises 341 amino acids and has a calculated molecular mass of 38.2 KDa.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Cynomolgus ACVR1B / ALK-4 Protein (Fc Tag) SDS-PAGE
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