-
Product Name
Human HMGB1/HMG1 (His Tag) recombinant protein
- Documents
-
Description
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
-
Protein name
High mobility group protein B1
-
Protein short names
DEF; MCG_144566; HMG-1; SBP-1; HMG3; MGC103168; DKFZP686A04236; MGC117896; P30; MGC117897; HMGB1; MGC103169; AMPHOTERIN; HMG1
-
Uniprot ID
P09429
-
Gene Name
HMGB1; HMG1
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human HMGB1 (P09429) (Lys57-Asp158) was expressed with a polyhistidine tag at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human HMGB1 consists of 117 amino acids and predicts a molecular mass of 13.6 KDa. It migrates as an approximately 15 KDa band in SDS-PAGE under reducing conditions.
-
Purity
> 90 % as determined by SDS-PAGE
-
Activity
Immobilized human His-HMGB1 at 10 μg/ml (100 μl/well) can bind AGER-Fc (Cat:501347) with a linear range of 0.31-2.5 μg/ml.
-
Validations
Human HMGB1 / HMG1 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"