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Product Name
Mouse HGF / Hepatocyte Growth Factor (His Tag) recombinant protein
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Description
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
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Protein name
Hepatocyte growth factor
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Protein short names
DFNB39; HPTA; HGF; NK1; SF; HGFB; HGF/SF; NK2; C230052L06RIK; F-TCF; SF/HGF
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Uniprot ID
Q08048
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Gene Name
Hgf
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse HGF (Q08048-1) (Met1-Leu728) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse HGF comprises 707 amino acids and has a predicted molecular mass of 80.8 kDa. The apparent molecular mass of the protein is approximately 92 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 70 % as determined by SDS-PAGE
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Activity
Measured by its ability to neutralize TGF-beta mediated inhibition on Mv-1-Lu cell proliferation.
The ED50 for this effect is typically 1-8 ng/mL. -
Validations
Mouse HGF / Hepatocyte Growth Factor Protein (His Tag) SDS-PAGE
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