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Human HGF / Hepatocyte Growth Factor recombinant protein

Cat.#: 502454

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Special Price 2224.8 USD

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Product Information

  • Product Name
    Human HGF / Hepatocyte Growth Factor recombinant protein
  • Documents
  • Description
    Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
  • Protein name
    Hepatocyte growth factor
  • Protein short names
    SF/HGF; F-TCF; C230052L06RIK; HGF/SF; NK2; HGFB; SF; NK1; HGF; HPTA; DFNB39
  • Uniprot ID
    P14210
  • Gene Name
    HGF; HPTA
  • Source/Expression Host
    CHO Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human HGF (NP_000592.3) precursor (Met 1-Ser 728) was expressed and purified.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human HGF consists of 697 amino acids after cleavage of the signal peptide and has a predicted molecular mass of 79.7 kDa. The HGF single chain can be processed into the active form of disulfide-linked heterodimer of ? and ? chain. As a result of glycosylation, it migrates with the apparent molecular mass of 90, 60 and 34 kDa corresponding to the single chain, ? chain and ? chain respectively in SDS-PAGE under reducing conditions.
  • Purity
    > 93 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to neutralize TGF-beta mediated inhibition on Mv-1-Lu cell proliferation.
    The ED50 for this effect is typically 2-10 ng/mL.
  • Validations

    Human HGF / Hepatocyte Growth Factor Protein SDS-PAGE

    Human HGF / Hepatocyte Growth Factor Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"