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Product Name
Mouse SerpinD1 (His Tag) recombinant protein
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Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
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Protein name
Heparin cofactor 2
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Protein short names
AA985900; D22S673; HCII; LS2; SERPIND1; MGC107662; AI303446; HCF2; HC2; HLS2
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Uniprot ID
Q5FW62
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Gene Name
Serpind1; Hcf2; Hcii
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse SerpinD1 precursor (NP_032249.3) (Met1-Ser 478) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse SerpinD1 consists of 466 amino acids and predicts a molecular mass of 53.5 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rmSerpinD1 is approximately 65-70 kDa as a result of glycosylation.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit thombin (Sigma, T4648) cleavage of fluorogenic peptide substrate Boc-VPR-AMC (R&D Systems, Catslog# ES011). The IC50 value is < 1.2 nM.
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Validations
Mouse SerpinD1 / HCII Protein (His Tag) SDS-PAGE
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