Anti-SerpinD1 antibody

Cat.#: 102379

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Product Information

  • Product Name
    Anti-SerpinD1 antibody
  • Documents
  • Description
    Rabbit polyclonal to SerpinD1
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Mouse SerpinD1 / HCII
  • Alternative names
    AA985900 antibody; AI303446 antibody; D22S673 antibody; HC2 antibody; HCF2 antibody; Hcf2 antibody; HCII antibody; HCII antibody; HLS2 antibody; LS2 antibody; MGC107662 antibody; SERPIND1 antibody; SerpinD1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Mouse SerpinD1 (rM SerpinD1; NP_032249.3; Met 1-Ser 478). SerpinD1 specific IgG was purified by mouse SerpinD1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA: 0.5-1.0 μg/mL

    This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse SerpinD1. The detection limit for Mouse SerpinD1 is 0.00245 ng/well.

    IHC-P: 0.1-2 μg/mL

  • Validations

    SerpinD1 / HCII Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    SerpinD1 / HCII Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of mouse SERPIND1 in mouse liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.

  • Background
    SerpinD1, also known as heparin cofactor II (HCâ…¡), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
  • References
    • Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.
    • Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"