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Product Name
Human SerpinD1 (His Tag) recombinant protein
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Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
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Protein name
Heparin cofactor 2
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Protein short names
SERPIND1; MGC107662; LS2; HCII; D22S673; AA985900; HLS2; HC2; AI303446; HCF2
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Uniprot ID
Q8IVC0
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Gene Name
SERPIND1; HCF2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SerpinD1 precursor (NP_000176.2) (Met 1-Ser 499) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The mature recombinant human SerpinD1 consists of 491 amino acids and predicts a molecular mass of 56.4 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhSerpinD1 is approximately 65-70 kDa as a result of glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized recombinant human SerpinD1-His (Cat:503095) at 10 μg/ml (100 μl/well) can bind biotinylated recombinant mouse ELANE-His (Cat:50204-M08H) with a linear range of 0.15-10.0 μg/ml. -
Validations
Human SerpinD1 Protein (His Tag) SDS-PAGE
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