FOLR1 antibody

Cat.#: 110743

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Product Information

  • Product Name
    FOLR1 antibody
  • Documents
  • Description
    FOLR1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, MCF-7 cells. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 38 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Adult folate binding protein antibody; FBP antibody; Folate receptor 1 antibody; folate receptor 1 (adult) antibody; Folate receptor alpha antibody; Folate receptor antibody; adult antibody; FOLR antibody; FOLR1 antibody; FR alpha antibody; KB cells FBP antibody; MOv18 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FOLR1 recombinant protein (Accession Number: NM_016725). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IF: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:110743(FOLR1 Antibody) at dilution of 1:800

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:110743(FOLR1 Antibody) at dilution of 1:800

    Immunofluorescent analysis of HeLa cells using Catalog No:110743(FOLR1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of HeLa cells using Catalog No:110743(FOLR1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    Folate receptor 1 (FOLR1), also known as folate receptor alpha or adult folate-binding protein (FBP), is a 38-kDa glycoprotein belonging to the folate receptor family (PMID:15094207; 23528302). The receptor binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. FOLR1 expression is often limited to the apical surfaces of epithelium in the lung, kidney and choroid plexus but is differentially overexpressed in a variety of solid tumors such as ovarian cancer, non-small cell lung cancer, breast cancer, kidney cancer and high-grade osteosarcoma (PMID: 23528302; 23357463).
  • References
    • Huang L, Tao K, Liu J. Design and Fabrication of Multifunctional Sericin Nanoparticles for Tumor Targeting and pH-Responsive Subcellular Delivery of Cancer Chemotherapy Drugs. ACS applied materials & interfaces. 2016.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"