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Product Name
FOLR1 antibody
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Description
FOLR1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, MCF-7 cells. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 38 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human; other species not tested.
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Alternative names
Adult folate binding protein antibody; FBP antibody; Folate receptor 1 antibody; folate receptor 1 (adult) antibody; Folate receptor alpha antibody; Folate receptor antibody; adult antibody; FOLR antibody; FOLR1 antibody; FR alpha antibody; KB cells FBP antibody; MOv18 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of FOLR1 recombinant protein (Accession Number: NM_016725). Purification method: Antigen Affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:110743(FOLR1 Antibody) at dilution of 1:800
Immunofluorescent analysis of HeLa cells using Catalog No:110743(FOLR1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
Folate receptor 1 (FOLR1), also known as folate receptor alpha or adult folate-binding protein (FBP), is a 38-kDa glycoprotein belonging to the folate receptor family (PMID:15094207; 23528302). The receptor binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. FOLR1 expression is often limited to the apical surfaces of epithelium in the lung, kidney and choroid plexus but is differentially overexpressed in a variety of solid tumors such as ovarian cancer, non-small cell lung cancer, breast cancer, kidney cancer and high-grade osteosarcoma (PMID: 23528302; 23357463).
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References
- Huang L, Tao K, Liu J. Design and Fabrication of Multifunctional Sericin Nanoparticles for Tumor Targeting and pH-Responsive Subcellular Delivery of Cancer Chemotherapy Drugs. ACS applied materials & interfaces. 2016.
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