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  • Cynomolgus B7-H3/CD276 (Fc Tag) recombinant protein

Cynomolgus B7-H3/CD276 (Fc Tag) recombinant protein

Cat.#: 504422

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Product Information

  • Product Name
    Cynomolgus B7-H3/CD276 (Fc Tag) recombinant protein
  • Documents
  • Description
    B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.
  • Protein short names
    6030411F23RIK; B7RP-2; 4IG-B7-H3; AU016588; B7-H3; B7H3; PSEC0249; CD276
  • Uniprot ID
    F7G5V3
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cynomolgus CD276 (XP_005560056.1) (Met1-Glu465) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Cynomolgus
  • Molecular weight
    The recombinant cynomolgus CD276 consists 675 amino acids and predicts a molecular mass of 73.8 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Cynomolgus B7-H3 / CD276 Protein (Fc Tag)

    Cynomolgus B7-H3 / CD276 Protein (Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"