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Anti-PI3 Kinase p85 alpha (1C8) Mouse antibody

Cat.#: 168164

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Product Information

  • Product Name
    Anti-PI3 Kinase p85 alpha (1C8) Mouse antibody
  • Documents
  • Description
    PI3 Kinase p85 alpha (1C8) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Rat, Mouse
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant protein expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1;000-2;000

    IHC: 1/100-200

  • Validations

    Immunohistochemical analysis of paraffin-embedded Rat Liver Tissue using PI3 Kinase P85 α Mouse mAb diluted at 1:200.

    Immunohistochemical analysis of paraffin-embedded Rat Liver Tissue using PI3 Kinase P85 α Mouse mAb diluted at 1:200.

    Western blot analysis of 1)3T3, 2) Rat LiverTissue with PI3 Kinase P85α Mouse mAb diluted at 1:2,000.

    Western blot analysis of 1)3T3, 2) Rat LiverTissue with PI3 Kinase P85α Mouse mAb diluted at 1:2,000.

    Western blot detection of PI3 Kinase p85α in Jurkat,Rat Brain,Raw264.7,Ramos,Raji cell lysates using PI3 Kinase p85α (1C8) Mouse mAb(1:1000 diluted).Predicted band size:85KDa.Observed band size:85KDa.

    Western blot detection of PI3 Kinase p85α in Jurkat,Rat Brain,Raw264.7,Ramos,Raji cell lysates using PI3 Kinase p85α (1C8) Mouse mAb(1:1000 diluted).Predicted band size:85KDa.Observed band size:85KDa.

    Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using PI3 Kinase P85 α Mouse mAb diluted at 1:200.

    Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using PI3 Kinase P85 α Mouse mAb diluted at 1:200.

  • Background
    Swiss-Prot Acc.P27986.Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"