Anti-phospho-Met (c-Met) (Tyr1349) Rabbit antibody

Cat.#: 167584

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Product Information

  • Product Name
    Anti-phospho-Met (c-Met) (Tyr1349) Rabbit antibody
  • Documents
  • Description
    phospho-Met (c-Met) (Tyr1349) Rabbit monoclonal antibody
  • Tested applications
    WB, IHC-P, IP
  • Species reactivity
    Human
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic phosphopeptide corresponding to residues surrounding Tyr1349 of human Met
  • Clonality
    Monoclonal
  • Formulation
    50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

    IHC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of phospho-Met (c-Met) (Tyr1349) in Hela,A549 cell lysates using phospho-Met (c-Met) (Tyr1349) Rabbit mAb(1:1000 diluted).Predicted band size:156kDa.Observed band size:170-140kDa.

    Western blot detection of phospho-Met (c-Met) (Tyr1349) in Hela,A549 cell lysates using phospho-Met (c-Met) (Tyr1349) Rabbit mAb(1:1000 diluted).Predicted band size:156kDa.Observed band size:170-140kDa.

  • Background
    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"