Anti-HP1 gamma/CBX3 Rabbit antibody

Anti-HP1 gamma/CBX3 Rabbit antibody

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• Material Safety Data Sheets (MSDS)

HP1 gamma/CBX3 Rabbit monoclonal antibody

WB, IHC-P, FC, IP

Human, Mouse, Rat

HECH; HP1-GAMMA; HP1Hs-gamma antibody

Rabbit IgG

Antigen: A synthetic peptide of human HP1 gamma

Monoclonal

50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.Q13185.Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).