Cart 2

Anti-HP1 gamma/CBX3 (6D8) Mouse antibody

Cat.#: 168146

Size:

Special Price 441.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-HP1 gamma/CBX3 (6D8) Mouse antibody
  • Documents
  • Description
    HP1 gamma/CBX3 (6D8) Mouse monoclonal antibody
  • Tested applications
    WB, IHC-P
  • Species reactivity
    Human, Rat, Mouse
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant protein expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1;000-2;000

    IHC: 1/100-200

  • Validations

    Western blot detection of HP1γ in MCF7,Raw264.7,Hela cell lysates using HP1γ (6D8) Mouse mAb(1:1000 diluted).Predicted band size:24KDa.Observed band size:24KDa.

    Western blot detection of HP1γ in MCF7,Raw264.7,Hela cell lysates using HP1γ (6D8) Mouse mAb(1:1000 diluted).Predicted band size:24KDa.Observed band size:24KDa.

    Western blot analysis of 1) Hela Cell Lysate, 2)3T3 Cell Lysate, 3) PC12 Cell Lysate using HP-1γ Mouse mAb diluted at 1:1000.

    Western blot analysis of 1) Hela Cell Lysate, 2)3T3 Cell Lysate, 3) PC12 Cell Lysate using HP-1γ Mouse mAb diluted at 1:1000.

    Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using HP-1γ Mouse mAb diluted at 1:200.

    Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using HP-1γ Mouse mAb diluted at 1:200.

    Immunohistochemical analysis of paraffin-embedded Human Placenta Tissue using HP-1γ Mouse mAb diluted at 1:200.

    Immunohistochemical analysis of paraffin-embedded Human Placenta Tissue using HP-1γ Mouse mAb diluted at 1:200.

  • Background
    Swiss-Prot Acc.Q13185.Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"