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Product Name
Anti-FADD Rabbit antibody
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Description
FADD Rabbit monoclonal antibody
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Tested applications
WB, FC, IP
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Species reactivity
Mouse, Rat
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Alternative names
GIG3; MORT1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human FADD
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of FADD in Rat Brain,3T3 cell lysates using FADD Rabbit mAb(1:1000 diluted).Predicted band size:23kDa.Observed band size:28kDa.
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Background
Swiss-Prot Acc.Q13158.Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"