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Product Name
Anti-FADD Rabbit antibody
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Description
FADD Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, FC
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Species reactivity
Mouse
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Alternative names
Mort1/FADD antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of mouse FADD
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
IHC: 1/20-1/50
FC: 1/20
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Validations
Western blot detection of FADD in SHSY-5Y cell lysates using FADD Rabbit pAb(1:1000 diluted).Predicted band size:23KDa.Observed band size:28KDa.
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Background
Swiss-Prot Acc.Q61160.Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"