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Product Name
Anti-CSF2RB antibody
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Description
Rabbit Polyclonal to Mouse CSF2RB
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Tested applications
IHC-P
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Species reactivity
Mouse CD131 / CSF2RB / IL3RB / IL5RB
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Alternative names
CD131 antibody; IL3RB antibody; IL5RB antibody; SMDP5 antibody; CDw131 antibody; Bc antibody; Il3r antibody; AIC2B antibody; Il3rb antibody; Il5rb antibody; CDw131 antibody; Il3rb1 antibody; Csf2rb1 antibody; Csfgmrb antibody; AI848964 antibody; AI848964 antibody; AIC2B antibody; Bc antibody; CD131 antibody; CDw131 antibody; CDw131 antibody; CSF2RB antibody; Csf2rb1 antibody; Csfgmrb antibody; GM-CSF/IL-3/IL-5 receptor common beta-chain antibody; GM-CSF/IL-3/IL-5 receptor common beta-chain antibody; Il3r antibody; IL3RB antibody; Il3rb antibody; Il3rb1 antibody; Il5rb antibody; IL5RB antibody; MGC130522 antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse CD131 / CSF2RB / IL3RB / IL5RB, and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 0.5-5 μg/mL
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Validations
CD131 / CSF2RB / IL3RB / IL5RB Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Background
Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"