Anti-CD131/CSF2RB/IL3RB/IL5RB antibody

Anti-CD131/CSF2RB/IL3RB/IL5RB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to CD131/CSF2RB/IL3RB/IL5RB

FCM

Human CD131 / CSF2RB / IL3RB / IL5RB

CD131 antibody; IL3RB antibody; IL5RB antibody; SMDP5 antibody; CDw131 antibody; Bc antibody; Il3r antibody; AIC2B antibody; Il3rb antibody; Il5rb antibody; CDw131 antibody; Il3rb1 antibody; Csf2rb1 antibody; Csfgmrb antibody; AI848964 antibody; AI848964 antibody; AIC2B antibody; Bc antibody; CD131 antibody; CDw131 antibody; CDw131 antibody; CSF2RB antibody; Csf2rb1 antibody; Csfgmrb antibody; GM-CSF/IL-3/IL-5 receptor common beta-chain antibody; GM-CSF/IL-3/IL-5 receptor common beta-chain antibody; Il3r antibody; IL3RB antibody; Il3rb antibody; Il3rb1 antibody; Il5rb antibody; IL5RB antibody; MGC130522 antibody

Mouse IgG1

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD131 / CSF2RB / IL3RB / IL5RB (rh CD131 / CSF2RB / IL3RB / IL5RB; NP_000386.1; Met1-Trp443). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

• Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
• Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
• Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.