Anti-CD131/CSF2RB/IL3RB/IL5RB antibody

Cat.#: 104299

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Product Information

  • Product Name
    Anti-CD131/CSF2RB/IL3RB/IL5RB antibody
  • Documents
  • Description
    Mouse monoclonal to CD131/CSF2RB/IL3RB/IL5RB
  • Tested applications
    FCM
  • Species reactivity
    Human CD131 / CSF2RB / IL3RB / IL5RB
  • Alternative names
    CD131 antibody; IL3RB antibody; IL5RB antibody; SMDP5 antibody; CDw131 antibody; Bc antibody; Il3r antibody; AIC2B antibody; Il3rb antibody; Il5rb antibody; CDw131 antibody; Il3rb1 antibody; Csf2rb1 antibody; Csfgmrb antibody; AI848964 antibody; AI848964 antibody; AIC2B antibody; Bc antibody; CD131 antibody; CDw131 antibody; CDw131 antibody; CSF2RB antibody; Csf2rb1 antibody; Csfgmrb antibody; GM-CSF/IL-3/IL-5 receptor common beta-chain antibody; GM-CSF/IL-3/IL-5 receptor common beta-chain antibody; Il3r antibody; IL3RB antibody; Il3rb antibody; Il3rb1 antibody; Il5rb antibody; IL5RB antibody; MGC130522 antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD131 / CSF2RB / IL3RB / IL5RB (rh CD131 / CSF2RB / IL3RB / IL5RB; NP_000386.1; Met1-Trp443) and conjugated with PE under optimum conditions, the unreacted PE was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD131 / CSF2RB / IL3RB / IL5RB Antibody (PE), Mouse MAb, Flow cytometric analysis

    CD131 / CSF2RB / IL3RB / IL5RB Antibody (PE), Mouse MAb, Flow cytometric analysis

    Flow cytometric analysis of human CSF2RB(CD131) expression on TF-1 cells. TF-1 cells were stained with PE-conjugated anti-human CSF2RB(CD131). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

  • Background
    Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
  • References
    • Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
    • Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
    • Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"