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Product Name
Anti-Caspase-9 Rabbit antibody
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Description
Caspase-9 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, IP
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Species reactivity
Human, Mouse
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthesized peptide derived from human Caspase-9
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Clonality
Polyclonal
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Formulation
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/500-1/2000
IHC: 1/50-1/200
ICC/IF: 1/50-1/200
IP: 1/50
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Validations
Western blot analysis of Caspase-9 expression in HeLa cell lysate.
Immunohistochemical analysis of paraffin-embedded human liver, using Caspase-9 Antibody.
Immunofluorescent analysis of HeLa cells treated with staurosporine, using Caspase-9 Antibody.
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Background
Swiss-Prot Acc.P55211.Caspase-9 is an important member of the cysteine aspartic acid protease (caspase) family. Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"