Anti-Casein Kinase 1 alpha Rabbit antibody
Casein Kinase 1 alpha Rabbit monoclonal antibody
Human, Mouse, Rat
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p antibody
Antigen: A synthetic peptide of human Casein Kinase 1 alpha
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of Casein Kinase 1 alpha in K562,Rat Brain,C6,Hela cell lysates using Casein Kinase 1 alpha Rabbit mAb(1:1000 diluted).Predicted band size:39kDa.Observed band size:34kDa.
Swiss-Prot Acc.P48729.Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
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