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Product Name
Anti-Casein Kinase 1 alpha Rabbit antibody
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Description
Casein Kinase 1 alpha Rabbit monoclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Casein Kinase 1 alpha
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000-1/5000
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Validations
Western blot detection of Casein Kinase 1 alpha in LnCap,K562,U251MG,MCF7,Hela cell lysates using Casein Kinase 1 alpha Rabbit mAb(1:500 diluted).Predicted band size:39kDa.Observed band size:34kDa.
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Background
Swiss-Prot Acc.P48729.Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"