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Product Name
Anti-beta Arrestin 1 (6A1) Mouse antibody
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Description
beta Arrestin 1 (6A1) Mouse monoclonal antibody
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Tested applications
WB
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Species reactivity
Human
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Alternative names
ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1. antibody
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Isotype
Mouse IgG2b
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Preparation
Antigen: Recombinant human β-Arrestin 1 protein.
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Clonality
Monoclonal
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Formulation
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/500
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Validations
Western blot detection of u03b2-Arrestin 1 in K562 and Hela cell lysates using u03b2-Arrestin 1 mouse mAb(dilution 1:500).Predicted band size:51kDa.Observed band size:51kDa.
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Background
Swiss-Prot Acc.P49407.Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling. Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"