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Product Name
Anti-phospho-beta Arrestin 1 (Ser412) Rabbit antibody
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Description
phospho-beta Arrestin 1 (Ser412) Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, IP
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Species reactivity
Human, Mouse, Rat
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Isotype
IgG
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Preparation
Antigen: A synthetic phosphopeptide corresponding to residues surrounding Ser412 of human beta Arrestin 1
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/5000
IHC: 1/100
ICC/IF: 1/50
IP: 1/20
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Validations
Western blot detection of phospho-beta Arrestin 1 (Ser412) in A549,MCF-7,U251,HL-60 cell lysates using phospho-beta Arrestin 1 (Ser412) Rabbit mAb(1:1000 diluted).Predicted band size:50kDa.Observed band size:50kDa.
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Background
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
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