Anti-Beclin 1 Rabbit antibody

Cat.#: 166861

Size:

Special Price 441.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-Beclin 1 Rabbit antibody
  • Documents
  • Description
    Beclin 1 Rabbit polyclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    ATG6; VPS30; beclin1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human Beclin 1
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000

  • Validations

    Western blot detection of Beclin 1 in MCF-7 cell lysates using Beclin 1 Rabbit pAb(1:1000 diluted).Predicted band size:52KDa.Observed band size:52KDa.

    Western blot detection of Beclin 1 in MCF-7 cell lysates using Beclin 1 Rabbit pAb(1:1000 diluted).Predicted band size:52KDa.Observed band size:52KDa.

  • Background
    Swiss-Prot Acc.Q14457.Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"