Mouse Adiponectin/Acrp30 (His Tag) recombinant protein
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Protein short names
ADIPO; ADIPONECTIN; ACRP30; APN; 30KDA; APM-1; APM1; ADPN; ACDC; ADIPOQ; AD; ADIPQTL1; GBP28
Adipoq; Acdc; Acrp30; Apm1
A DNA sequence encoding the mouse ADIPOQ (NP_033735.3) (Met 1-Asn 247) was expressed, with a C-terminal polyhistidine tag.
The secreted recombinant mouse ADIPOQ comprises 241 amino acids and has a calculated molecular mass of 26.4 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
> 95 % as determined by SDS-PAGE
Mouse Adiponectin / Acrp30 / ADIPOQ Protein (His Tag) SDS-PAGE
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