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Product Name
Anti-Adiponectin Rabbit antibody
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Description
Adiponectin Rabbit monoclonal antibody
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Tested applications
WB, IP
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Species reactivity
Human
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Alternative names
ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Adiponectin
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000-1:5000
1:20
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Validations
Western blot detection of Adiponectin in K562,Hela cell lysates using Adiponectin Rabbit mAb(1:1000 diluted).Predicted band size:26kDa.Observed band size:30kDa.
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Background
Swiss-Prot Acc.Q15848.Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"