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Product Name
Canine IL-22R / IL22RA1 (Fc Tag) recombinant protein
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Description
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
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Protein name
Uncharacterized protein
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Protein short names
IL22RA1; IL-22R; IL22R; IL22R1; 9130219A07RIK; ENSMUSG00000073746; RP23-110F21.4; CRF2-9
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Uniprot ID
J9NT69
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Gene Name
IL22RA1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-Thr226) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine IL22RA1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 453 amino acids and has a predicted molecular mass of 51.2 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Canine IL22RA1 / IL22R Protein (Fc Tag) SDS-PAGE
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