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Product Name
IL22RA1 Polyclonal Antibody
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Description
Polyclonal antibody to IL22RA1
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Tested applications
WB
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Species reactivity
Human
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Alternative names
IL22RA1 antibody; CRF2-9 antibody; IL22R antibody; IL22R1 antibody; interleukin-22 receptor subunit alpha-1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human IL22RA1
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
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Validations
Western blot - IL22RA1 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using IL22RA1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 5s.
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Background
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"