Canine IL-22R / IL22RA1 (His Tag) recombinant protein

Canine IL-22R / IL22RA1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Uncharacterized protein

IL22R; IL-22R; IL22RA1; CRF2-9; RP23-110F21.4; 9130219A07RIK; IL22R1; ENSMUSG00000073746

J9NT69

IL22RA1

Human Cells

A DNA sequence encoding the canine IL22RA1 (XP_855113.2) (Met1-The226) was expressed with a C-terminal polyhistidine tag.

Canine

The recombinant canine IL22RA1 comprises 223 amino acids and has a predicted molecular mass of 25.6 kDa. The apparent molecular mass of the protein is approximately 36 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Immobilized canine IL22RA1-His at 10 μg/ml (100 μl/well) can bind biotinylated IL22 (Cat:502557), The EC₅₀ of biotinylated IL22 (Cat:502557) is 0.23-0.55 μg/ml.