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Product Name
Rat IL-22R / IL22RA1 (Fc Tag) recombinant protein
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Description
IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
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Protein name
Protein Il22ra1
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Protein short names
RP23-110F21.4; ENSMUSG00000073746; 9130219A07RIK; IL22R1; IL22RA1; IL-22R; CRF2-9; IL22R
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Uniprot ID
D3ZIM3
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Gene Name
Il22ra1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat Il22ra1 (NP_001178798.1) (Met1-Ala228) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat Il22ra1 consists 449 amino acids and predicts a molecular mass of 50.8 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Rat IL-22R / IL22RA1 Protein (Fc Tag)
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