Rhesus IGFBP1/IGFBP-1 (His Tag) recombinant protein

Rhesus IGFBP1/IGFBP-1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Uncharacterized protein

RP23-20C9.2; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1); IGFBP-1; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; IBP-1; PP12; IGF-BINDING PROTEIN 1; HIGFBP-1; IBP1; IGF-BP25; AFBP

F6RF22

IGFBP1; EGK_13713

Human Cells

A DNA sequence encoding the rhesus IGFBP1 (XP_001085935.2) (Met23-Asn281) was expressed, fused with a polyhistidine tag at the C-terminus.

Rhesus

The recombinant rhesus comprises 245 amino acids and has a calculated molecular mass of 26.7 KDa.

> 98 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA.
Immobilized Rhesus IGFBP1-His at 10 μg/ml (100 μl/well) can bind biotinylated human IGF1 (Cat:10598-H24E) with a linear range of 12.5-100 ng/ml.