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Product Name
Canine IGFBP1/IGFBP-1 (His Tag) recombinant protein
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Description
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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Protein name
Uncharacterized protein
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Protein short names
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1); PP12; AFBP; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1; IGF-BP25; IBP1; HIGFBP-1; IGF-BINDING PROTEIN 1; IGFBP-1; RP23-20C9.2; IBP-1
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Uniprot ID
F1PSW9
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Gene Name
IGFBP1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine IGFBP1 (XP_005629556.1) (Met1-Ser249) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine IGFBP1 consists 235 amino acids and predicts a molecular mass of 26 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Canine IGFBP1 / IGFBP-1 Protein (His Tag)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"