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Product Name
Human CD40/TNFRSF5 (His Tag) recombinant protein
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Description
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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Protein name
Tumor necrosis factor receptor superfamily member 5
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Protein short names
TRAP; RP23-428M13.1; MGC9013; GP39; BP50; TNFRSF5; HIGM1; CD40; IGM; T-BAM; CDW40; IMD3; AI326936; P50
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Uniprot ID
Q6P2H9
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Gene Name
CD40; TNFRSF5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human CD40 (NP_001241.1) extracellular domain (Met 1-Arg 193) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human CD40 comprises 184 amino acids with a predicted molecular mass of 20.7 kDa. As a result of glycosylation, rhCD40 migrates as an approximately 32 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD40 at 2 μg/ml (100 μl/well) can bind biotinylated human CD40L with a linear range of 15.6-500 ng/ml.
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Validations
Human CD40 / TNFRSF5 Protein (His Tag) SDS-PAGE
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