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Product Name
Mouse CD40/TNFRSF5 (His & Fc Tag) recombinant protein
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Description
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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Protein name
Tumor necrosis factor receptor superfamily member 5
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Protein short names
P50; CDW40; IMD3; AI326936; CD40; HIGM1; TNFRSF5; BP50; T-BAM; IGM; RP23-428M13.1; TRAP; GP39; MGC9013
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Uniprot ID
P27512
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Gene Name
Cd40; Tnfrsf5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse CD40 isoform 1 (P27512-1) (Met 1-Arg 193) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse CD40/Fc is a disulfide-linked homodimer The reduced monomer comprises 422 amino acids and has a predicted molecular mass of 47 kDa. As a result of glycosylation, it migrates as an approximately 57 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind recombinant human CD40L in a functional ELISA.
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Validations
Mouse CD40 / TNFRSF5 Protein (His & Fc Tag) SDS-PAGE
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