Human NGFR/P75 (Fc Tag) recombinant protein

Human NGFR/P75 (Fc Tag) recombinant protein

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Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Tumor necrosis factor receptor superfamily member 16

TNFRSF16; GP80-LNGFR; P75; CD271; P75NTR; P75(NTR); RP23-67E18.6; P75NGFR; LNGFR

P08138

NGFR; TNFRSF16

Human Cells

A DNA sequence encoding the human NGFR (P08138) extracellular domain (Met 1-Asn 250) was fused with the Fc region of human IgG1 at the C-terminus.

Human

The secreted recombinant human NGFR/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a predicted molecular mass of 50.6 kDa. The apparent molecular mass of rhNGFR/Fc monomer is approximately 70-80 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE

Measured by its ability to inhibit NGF dependent proliferation of TF-1 human erythroleukemic cells.
The ED₅₀ for this effect is typically 0.5-3 μg/mL in the presence of 4 ng/mL Recombinant Human NGF.