Human NGFR/P75 (His Tag) recombinant protein

Human NGFR/P75 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. High-affinity nerve growth factor receptor is also referred as Trk familywhose members are bound by some neurotrophins with high affinity. Nerve growth factor binds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to the cell body. The Low-affinity nerve growth factor receptor also named p75 which binds with all kinds of neurotrophins with low affinity. All the four kinds of neurotrophins, including Nerve growth factor, Brain derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 bind to the p75. Studies have proved that NGFR acts as a molecular signal swith that determines cell death or survival by three steps. First, pro-nerve growth factor (prNGF) triggers cell apoptosis by its high affinity binding to p75NTR, while NGF induces neuronal survival with low-affinity binding. Second, p75NTR mediates cell death by combining with co-receptor sortilin, whereas it promotes neuronal survival through combination with proNGF. Third, release of the intracellular domain chopper or cleavage short p75 NTR can independently initiate neuronal apoptosis.

Tumor necrosis factor receptor superfamily member 16

LNGFR; RP23-67E18.6; P75NGFR; P75(NTR); P75NTR; P75; CD271; TNFRSF16; GP80-LNGFR

P08138

NGFR; TNFRSF16

Human Cells

A DNA sequence encoding the human NGFR (P08138) extracellular domain (Met 1-Asn 250) was fused with a polyhistidine tag at the C-terminus.

Human

The secreted recombinant human NGFR consists of 233 amino acids and has a predicted molecular mass of 25 kDa. The apparent molecular mass of rhNGFR is approximately 45-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE