-
Product Name
Human TNFRSF12A/FN14/TWEAKR (Fc Tag) recombinant protein
- Documents
-
Description
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
-
Protein name
Tumor necrosis factor receptor superfamily member 12A
-
Protein short names
TWEAKR; FGF-INDUCIBLE 14; FN14; TWEAK-R; TWEAK-RECEPTOR; TYPE I TRANSMEMBRANE PROTEIN FN14; FIBROBLAST GROWTH FACTOR REGULATED PROTEIN 2; HPIP; CD266; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A; FIBROBLAST GROWTH FACTOR-INDUCIBLE IMMEDIATE-EARLY RESPONSE PROTEIN 14
-
Uniprot ID
Q9NP84
-
Gene Name
TNFRSF12A; FN14
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the human TNFRSF12A isoform 1 (Q9NP84-1) extracellular domain (Glu 28-Trp 79) was fused with the Fc region of human IgG1 at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human TNFRSF12A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 313 amino acids and has a calculated molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTNFRSF12A/Fc monomer is approximately 37 kDa.
-
Purity
> 95 % as determined by SDS-PAGE
-
Activity
Immobilized Cynomolgus mFc-TNFSF12 (Cat:502405) at 10 μg/ml (100 μl/well) can bind human Fc-TNFRSF12A, The EC50 of human Fc-TNFRSF12A is 0.07-0.15 μg/ml.
-
Validations
Human TNFRSF12A / FN14 / TWEAKR Protein (Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"