Mouse Tnfrsf12a/Fgfrp2/Fn14 (Fc tag) recombinant protein

Cat.#: 518133

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Product Information

  • Product Name
    Mouse Tnfrsf12a/Fgfrp2/Fn14 (Fc tag) recombinant protein
  • Documents
  • Description
    Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. It plays an important role in the inflammatory processes of rheumatoid arthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA), and ankylosing spondylitis and the resulting joint pathology. In addition, TNF plays a role in the inflammatory process of plaque psoriasis. Elevated levels of TNF are found in involved tissues and fluids of patients with RA, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75), exist naturally as monomeric molecules on cell surfaces and in soluble forms. Biological activity of TNF is dependent upon binding to either cell surface TNFR.
  • Protein name
    tumor necrosis factor receptor superfamily, member 12a(Tnfrsf12a)
  • Protein short names
    Fgfrp2; Fn14
  • Uniprot ID
    Q9CR75
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Mouse Tnfrsf12a/Fgfrp2/Fn14 Glu28-Trp79 is expressed with a Fc tag at the C-terminus.
  • Protein Species
    Mouse
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Mouse Tnfrsf12a/Fgfrp2/Fn14 (Fc tag) recombinant protein

    Mouse Tnfrsf12a/Fgfrp2/Fn14 (Fc tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"