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Product Name
Mouse RANKL/OPGL/TNFSF11 (CD254) (Fc Tag) recombinant protein
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Description
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
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Protein name
Tumor necrosis factor ligand superfamily member 11
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Protein short names
CD254; OPGL; SODF; ODF; RANKL; LY109L; TRANCE; HRANKL2; RP11-86N24.2; TNFSF11; OPTB2; OPG
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Uniprot ID
O35235
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Gene Name
Tnfsf11; Opgl; Rankl; Trance
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse TNFSF11 (BAA97257.1) (Arg 72-Asp 316) was fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse TNFSF11/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a calculated molecular mass of 56 kDa. The apparent molecular mass of the monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
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Purity
> 87 % as determined by SDS-PAGE
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Activity
Immobilized mouse Fc-TNFSF11 at 10 μg/ml (100 μl/well) can bind biotinylated human TNFRSF11B-His (Cat:500115), The EC50 of biotinylated human TNFRSF11B-His (Cat:500115) is 0.07-0.17 μg/ml.
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Validations
Mouse RANKL / OPGL / TNFSF11 / CD254 Protein (Fc Tag) SDS-PAGE
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