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Product Name
Human tPA (Fc Tag) recombinant protein
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Description
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
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Protein name
Tissue-type plasminogen activator
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Protein short names
PLAT; TPA; MGC18508; D8ERTD2E; DKFZP686I03148; T-PA; AW212668; AU020998
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Uniprot ID
P00750
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Gene Name
PLAT
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the ? chain (Ile 311-Pro 562) of mature human tPA (NP_000921.1) was expressed with the fused Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human Fc/tPA ? is a disulfide-linked homodimeric protein. The reduced monomer consists of 489 amino acids and has a predicted molecular mass of 54.8 kDa. As a result of glycosylation, the apparent molecular mass of rh Fc/tPA? monomer is approximately 60-65 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human tPA / PLAT Protein (Fc Tag) SDS-PAGE
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