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Product Name
TIRAP Polyclonal Antibody
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Description
Polyclonal antibody to TIRAP
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Tested applications
IHC
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Species reactivity
Human
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Alternative names
TIRAP antibody; BACTS1 antibody; Mal antibody; MyD88-2 antibody; wyatt antibody; TIR domain containing adaptor protein antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IHC 1:50 - 1:200
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Validations
Immunohistochemistry - TIRAP Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human liver cancer using TIRAP antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - TIRAP Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human colon carcinoma using TIRAP antibody at dilution of 1:200 (40x lens).
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Background
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"